Christina Applegate’s Enduring Journey with MS: David Faustino Shares Insights Amidst ‘Married…With Children’ Reunion Buzz
The world watched with admiration and concern when acclaimed actress Christina Applegate publicly revealed her diagnosis with multiple sclerosis (MS) in 2021. Since then, her journey has been one of immense courage and transparency, inspiring countless individuals navigating similar health challenges. Recently, her former co-star from the iconic series Married…With Children, David Faustino, provided a heartfelt update on her condition, offering a glimpse into the realities she faces while highlighting her unwavering resilience. This update came during his appearance at the annual Race to Erase MS Gala in Los Angeles, California, an event dedicated to funding crucial research and raising awareness for the debilitating neurological condition.
Faustino, who portrayed Bud Bundy alongside Applegate’s Kelly Bundy, shared an intimate perspective on his dear friend’s battle. Speaking exclusively to HollywoodLife at the Fairmont Century Plaza event, he conveyed the profound impact of her diagnosis. “Christina is in her first year, it’s hard, it’s challenging, and she’s pushing through,” he stated, acknowledging the formidable nature of MS, especially in its early stages. His words underscore the immense strength Applegate has demonstrated as she adapts to a new reality, one that often demands significant adjustments to daily life and career pursuits. Their close bond, forged over years of working together and sustained through decades of friendship, clearly provides a vital source of support for Christina.
The depth of their friendship is evident in Faustino’s revelation that they “talk just about every day,” a testament to the enduring connection between the former castmates. This regular communication allows him to witness firsthand the strength Applegate draws upon daily. While Christina’s diagnosis undoubtedly “hit home” for David, his commitment to the cause of multiple sclerosis research predates her own battle. He has been a steadfast attendee of the Race to Erase MS Gala since its very inception 29 years ago. “I’ve been coming to this event since its inception, it’s my 29th year here,” he explained, elaborating on his long-standing dedication. “The reason it was so important to me up until this point is because of my relationship with Nancy Davis (the founder of Race to Erase MS), learning about MS, meeting her family and learning about the things that they’ve gone through. All of the fun that I’d had with them these past 29 years.” His consistent presence at the gala highlights the widespread impact of MS and the critical need for continued efforts in research and support.
Understanding Multiple Sclerosis: A Complex Journey
Multiple sclerosis is a chronic, often unpredictable disease of the central nervous system, which includes the brain, spinal cord, and optic nerves. It is believed to be an immune-mediated disorder, meaning the immune system mistakenly attacks healthy tissue, specifically the myelin sheath that surrounds nerve fibers. This damage disrupts the flow of information within the brain, and between the brain and the body, leading to a wide range of potential symptoms.
Symptoms of MS vary significantly from person to person, depending on which nerves are affected and the extent of the damage. They can include fatigue, numbness or tingling, muscle weakness, blurred vision, problems with balance and coordination, cognitive difficulties, and pain. The course of MS can also vary, with some individuals experiencing periods of remission and relapse (relapsing-remitting MS), while others face a more steadily progressive form of the disease. There is currently no cure for MS, but various treatments are available to manage symptoms, slow disease progression, and improve quality of life. Christina Applegate’s openness about her experience plays a crucial role in demystifying this complex condition and fostering greater understanding and empathy.
Before David’s latest appearance at Race to Erase MS, Christina made her MS diagnosis public in 2021, sharing the news directly with her followers on Twitter. Her candid tweet offered a raw and honest look into her initial reactions and the support she found. “A few months ago I was diagnosed with MS. It’s been a strange journey. But I have been so supported by people that I know who also have this condition. It’s been a tough road,” she wrote, expressing both vulnerability and gratitude for her community.

Her tweet continued with a message of perseverance and a request for privacy, reflecting her need to navigate this new chapter on her own terms. “But as we all know, the road keeps going,” she continued. “Unless some a**hole blocks it. As one of my friends with MS said, ‘We wake up and take the indicated action.’ And that’s what I do. So now I ask for privacy. As I go through this thing. Thank you xo.” This powerful statement perfectly encapsulates the mindset many individuals with chronic illnesses adopt: facing each day with intentionality and a commitment to action, even when the path ahead is uncertain. Christina’s decision to share her struggle has been a beacon for many, breaking down stigmas and fostering a sense of community among those affected by MS.
The Enduring Legacy of ‘Married…With Children’ and a New Chapter
Beyond the personal updates on Applegate’s health, another exciting development has captured the attention of fans worldwide: the impending return of the original Married…With Children cast. David’s update about Christina’s MS comes just days after the announcement that the beloved sitcom’s original stars, including Katey Sagal (Peggy Bundy) and Ed O’Neill (Al Bundy), alongside Applegate and Faustino, will be lending their voices to an animated reboot of the series. This news, reported by The Hollywood Reporter, has generated significant buzz and anticipation among long-time followers of the iconic show.

The animated revival promises to bring the dysfunctional yet lovable Bundy family back to television screens in a fresh format. With Family Guy writer and executive producer Alex Carter set to serve as the showrunner, expectations are high for a series that will honor the original’s irreverent humor while appealing to a new generation of viewers. The project is currently being taken to potential buyers, indicating that fans may not have to wait much longer to see the Bundys’ animated antics. The participation of the original cast members underscores their enduring chemistry and the special bond they share, a bond that clearly extends beyond the set into their personal lives.
The Power of Celebrity Advocacy and Community Support
Christina Applegate’s decision to go public with her MS diagnosis, much like other celebrities who have shared their health battles, has a profound impact. It elevates awareness of the disease, encourages open dialogue, and helps destigmatize chronic conditions. Her candidness provides a relatable face to a complex illness, showing that even those in the public eye face significant challenges and navigate vulnerability. This visibility can lead to increased funding for research, better public understanding, and a more supportive environment for individuals living with MS.
The Race to Erase MS Gala itself is a powerful example of community coming together. Founded by Nancy Davis, who was diagnosed with MS in 1991, the event has raised tens of millions of dollars for MS research. It symbolizes hope, progress, and the collective determination to find a cure. David Faustino’s consistent involvement, motivated by personal connections and a deep understanding of the cause, highlights the critical role that advocacy and support networks play. For Christina, knowing she has a friend like David, who not only checks in daily but also actively champions a cause so close to her heart, undoubtedly provides immense comfort and strength.
Looking Ahead: Resilience and Hope
As Christina Applegate continues her journey with multiple sclerosis, her story remains one of profound strength and an unyielding spirit. David Faustino’s recent update reminds us of the daily challenges she navigates but also underscores her steadfast determination to push through. The renewed connection of the Married…With Children cast for the animated reboot serves as a heartwarming testament to their enduring friendship and shared legacy, a legacy that now intertwines with Christina’s courageous advocacy for MS awareness. With dedicated friends, a supportive community, and ongoing advancements in medical research, there is tangible hope for a future where conditions like MS are better understood, managed, and ultimately, cured. Christina Applegate’s voice, both in her personal journey and through her iconic characters, continues to resonate and inspire.